SrasV1, France, Analysis, bibRecord, 000313

Detection of the New Human Coronavirus HKU1: A Report of 6 Cases

Identifieur interne : 000313 ( France/Analysis ); précédent : 000312; suivant : 000314

Detection of the New Human Coronavirus HKU1: A Report of 6 Cases

Auteurs : Astrid Vabret [France] ; Julia Dina [France] ; Stéphanie Gouarin [France] ; Joëlle Petitjean [France] ; Sandrine Corbet [France] ; François Freymuth [France]

Source :

Clinical Infectious Diseases [ 1058-4838 ] ; 2006.

RBID : ISTEX:6E40F5C402B962001B04C6BDCCEAE129AF7B4691

Abstract

Background. Human coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients. Methods. We screened 141 specimens (135 nasal samples and 6 stool samples) received in February and March 2005 in our laboratory and obtained from 135 hospitalized patients (61.5% of whom were <5 years old and 34.1% of whom were >20 years old) for HCoV-HKU1. Results. HCoV-HKU1 was detected in 6 (4.4%) of the 135 nasal specimens and in 2 (33.3%) of the 6 stool samples; the positive samples were obtained from 6 patients (5 children and 1 adult). The clinical presentation of these 6 patients was as follows: 3 were admitted to the hospital for acute enteric disease resulting in severe dehydration associated with upper respiratory symptoms; 1 had fever, otitis, and febrile seizure; 1 had a sample obtained to investigate failure to thrive; and 1 had a sample obtained for exploration of X-linked agammaglobulinemia and hyperleucocytosis. Conclusion. HCoV-HKU1 can be detected in respiratory and stool samples from children and adults in a part of the world other than Hong Kong. Our results suggest that HCoV-HKU1 could be associated with respiratory and enteric diseases, and its detection can be related to a persistent asymptomatic infection in patients with poor underlying conditions.

Url:

https://api.istex.fr/ark:/67375/HXZ-4FL1WQGZ-Z/fulltext.pdf

DOI: 10.1086/500136

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000578
to stream Istex, to step Curation: 000578
to stream Istex, to step Checkpoint: 001510
to stream Main, to step Merge: 004300
to stream Main, to step Curation: 004084
to stream Main, to step Exploration: 004084
to stream France, to step Extraction: 000313

Links to Exploration step

ISTEX:6E40F5C402B962001B04C6BDCCEAE129AF7B4691

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Detection of the New Human Coronavirus HKU1: A Report of 6 Cases</title>
<author><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
</author>
<author><name sortKey="Dina, Julia" sort="Dina, Julia" uniqKey="Dina J" first="Julia" last="Dina">Julia Dina</name>
</author>
<author><name sortKey="Gouarin, Stephanie" sort="Gouarin, Stephanie" uniqKey="Gouarin S" first="Stéphanie" last="Gouarin">Stéphanie Gouarin</name>
</author>
<author><name sortKey="Petitjean, Joelle" sort="Petitjean, Joelle" uniqKey="Petitjean J" first="Joëlle" last="Petitjean">Joëlle Petitjean</name>
</author>
<author><name sortKey="Corbet, Sandrine" sort="Corbet, Sandrine" uniqKey="Corbet S" first="Sandrine" last="Corbet">Sandrine Corbet</name>
</author>
<author><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6E40F5C402B962001B04C6BDCCEAE129AF7B4691</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1086/500136</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-4FL1WQGZ-Z/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000578</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000578</idno>
<idno type="wicri:Area/Istex/Curation">000578</idno>
<idno type="wicri:Area/Istex/Checkpoint">001510</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001510</idno>
<idno type="wicri:doubleKey">1058-4838:2006:Vabret A:detection:of:the</idno>
<idno type="wicri:Area/Main/Merge">004300</idno>
<idno type="wicri:Area/Main/Curation">004084</idno>
<idno type="wicri:Area/Main/Exploration">004084</idno>
<idno type="wicri:Area/France/Extraction">000313</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Detection of the New Human Coronavirus HKU1: A Report of 6 Cases</title>
<author><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">France</country>
<wicri:regionArea>Reprints or correspondence: Dr. Astrid Vabret, Laboratory of Virology, University Hospital of Caen, Ave. Georges Clemenceau, 14 033 Caen cedex</wicri:regionArea>
<wicri:noRegion>14 033 Caen cedex</wicri:noRegion>
<wicri:noRegion>14 033 Caen cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dina, Julia" sort="Dina, Julia" uniqKey="Dina J" first="Julia" last="Dina">Julia Dina</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gouarin, Stephanie" sort="Gouarin, Stephanie" uniqKey="Gouarin S" first="Stéphanie" last="Gouarin">Stéphanie Gouarin</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Petitjean, Joelle" sort="Petitjean, Joelle" uniqKey="Petitjean J" first="Joëlle" last="Petitjean">Joëlle Petitjean</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corbet, Sandrine" sort="Corbet, Sandrine" uniqKey="Corbet S" first="Sandrine" last="Corbet">Sandrine Corbet</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Virology, University Hospital of Caen, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Clinical Infectious Diseases</title>
<title level="j" type="abbrev">Clinical Infectious Diseases</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date type="published">2006</date>
<biblScope unit="vol">42</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="634">634</biblScope>
<biblScope unit="page" to="639">639</biblScope>
</imprint>
<idno type="ISSN">1058-4838</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Background. Human coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients. Methods. We screened 141 specimens (135 nasal samples and 6 stool samples) received in February and March 2005 in our laboratory and obtained from 135 hospitalized patients (61.5% of whom were <5 years old and 34.1% of whom were >20 years old) for HCoV-HKU1. Results. HCoV-HKU1 was detected in 6 (4.4%) of the 135 nasal specimens and in 2 (33.3%) of the 6 stool samples; the positive samples were obtained from 6 patients (5 children and 1 adult). The clinical presentation of these 6 patients was as follows: 3 were admitted to the hospital for acute enteric disease resulting in severe dehydration associated with upper respiratory symptoms; 1 had fever, otitis, and febrile seizure; 1 had a sample obtained to investigate failure to thrive; and 1 had a sample obtained for exploration of X-linked agammaglobulinemia and hyperleucocytosis. Conclusion. HCoV-HKU1 can be detected in respiratory and stool samples from children and adults in a part of the world other than Hong Kong. Our results suggest that HCoV-HKU1 could be associated with respiratory and enteric diseases, and its detection can be related to a persistent asymptomatic infection in patients with poor underlying conditions.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Basse-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Caen</li>
</settlement>
</list>
<tree><country name="France"><region name="Région Normandie"><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
</region>
<name sortKey="Corbet, Sandrine" sort="Corbet, Sandrine" uniqKey="Corbet S" first="Sandrine" last="Corbet">Sandrine Corbet</name>
<name sortKey="Dina, Julia" sort="Dina, Julia" uniqKey="Dina J" first="Julia" last="Dina">Julia Dina</name>
<name sortKey="Freymuth, Francois" sort="Freymuth, Francois" uniqKey="Freymuth F" first="François" last="Freymuth">François Freymuth</name>
<name sortKey="Gouarin, Stephanie" sort="Gouarin, Stephanie" uniqKey="Gouarin S" first="Stéphanie" last="Gouarin">Stéphanie Gouarin</name>
<name sortKey="Petitjean, Joelle" sort="Petitjean, Joelle" uniqKey="Petitjean J" first="Joëlle" last="Petitjean">Joëlle Petitjean</name>
<name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
<name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000313 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000313 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     ISTEX:6E40F5C402B962001B04C6BDCCEAE129AF7B4691
   |texte=   Detection of the New Human Coronavirus HKU1: A Report of 6 Cases
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Detection of the New Human Coronavirus HKU1: A Report of 6 Cases

Detection of the New Human Coronavirus HKU1: A Report of 6 Cases

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri